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History of genetics

     Genetics is the science of heredity and variability of living organisms and methods of their management.  It was based on the patterns of heredity discovered by Gregor Mendel when crossing pea varieties. Mendel chose peas, which have many varieties that differ in alternative manifestations of traits, as the object of study. The choice of the object turned out to be successful because the inheritance of traits in peas is quite clear. Peas are usually self-pollinated, although cross-pollination is also possible. In a self-pollinated plant, all offspring are the offspring of a single organism, i.e., they are the so-called pure line, and the ability to cross-pollinate facilitates hybridization (crossing). This gave Mendel the opportunity to analyze the offspring of each individual and the offspring resulting from hybridization. Before starting the experiments, Mendel checked the purity of the variety (homozygosity) for several years, and once he was sure of it, he began the experiment.

   
    Mendel analyzed the patterns of heredity both in cases where the parental organisms differed in the alternative manifestation of one trait (monohybrid crossing) and in cases where they differed in the alternative manifestations of several traits (di-, tri-polyhybrid crossing). According to the level of science at the time, Mendel could not yet link hereditary factors to certain cell structures.
   
    In 1900. H. de Fries, K. Korence and E. Cermak rediscovered Mendel's laws for the second time. Already in 1901-1903, H. de Fries created the mutational theory, which, together with G. Mendel's laws, laid the foundation for modern genetics. The term "genetics" was proposed in 1906 by W. Batson. As early as 1883-1884, V. Roux, O. Gertwig, E. Strasburger and A. Weismann proposed the nuclear hypothesis of heredity, which in the early 20th century developed into the chromosomal theory of heredity.

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Groups of genetic diseases

Diseases of protein metabolism    Autosomal Dominant Disorder    Autosomal recessive diseases    Chromosome syndromes    Diseases inoculated with the X-chromosome    Diseases of carbohydrate metabolism    Diseases of lipid metabolism    Polygenic diseases